Aortic Endothelial Cells
نویسنده
چکیده
Isolated, cultured arterial endothelial cells express an acetylcholine (ACh)-activated K current in addition to an inward rectifier current whose conductance Ls unaffected by ACh. The cholinergic K current is specifically blocked by atropine (1 /xM) and shows single saturation kinetics with ACh (halfmaximal stimulation 51 nM ACh). Unlike the cardiac muscarinic receptor-gated K channel, its stimulation appears independent of a pertussis toxin-sensitive GTP-binding protein. Activation of the endothelial muscarinic K current resulting in hyperpolarization may represent an initial component of the vasodilatory effect of ACh. (Circulation Research 1988;62:1059-1064)
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تاریخ انتشار 2005